Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi‐Ethnic Study of Atherosclerosis
Why the study?
Does an optimal Life's Simple 7 score reduce noncardiovascular disease events in adults aged 45-84 years?
Population
6,506 men and women aged between 45 and 84 years, enrolled in the Multi-Ethnic Study of Atherosclerosis.
Comparison
Optimal (11-14) Life's Simple 7 (LS7) score vs Inadequate (0-8) Life's Simple 7 (LS7) score
Design
Cohort
Follow-up
median 10.2 years
Authors
Discussion
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Overview
May encourage LS7 optimization in practice; extends CV metrics to nonvascular outcomes but needs trial confirmation.
Key Points
- To examine the association between the American Heart Association's Life's Simple 7 metrics and the incidence of noncardiovascular chronic diseases.
- Analyzed 6,506 men and women aged 45 to 84 years in the Multi-Ethnic Study of Atherosclerosis followed for a median of 10.2 years.
- Scored seven health metrics (smoking, BMI, physical activity, diet, cholesterol, blood pressure, blood glucose) on a 0–14 scale categorized as inadequate (0–8), average (9–10), and optimal (11–14).
- Calculated multivariable-adjusted hazard ratios for incident hospitalizations for cancer, chronic kidney disease, pneumonia, DVT/PE, COPD, dementia, and hip fracture.
- Compared with inadequate scores, an optimal LS7 score was associated with a reduced risk of chronic kidney disease (HR 0.38, 95% CI 0.27–0.54), COPD (HR 0.51, 95% CI 0.31–0.83), and DVT/PE (HR 0.52, 95% CI 0.33–0.82).
- Optimal LS7 scores also significantly reduced the risk of pneumonia (HR 0.57, 95% CI 0.40–0.80) and cancer (HR 0.80, 95% CI 0.64–0.98).
Structured PICO
Does an optimal Life's Simple 7 score reduce noncardiovascular disease events in adults aged 45-84 years?
P
Population
6,506 men and women aged between 45 and 84 years, enrolled in the Multi-Ethnic Study of Atherosclerosis.
I
Intervention
Optimal (11-14) Life's Simple 7 (LS7) score
C
Comparator
Inadequate (0-8) Life's Simple 7 (LS7) score
O
Outcome
Noncardiovascular disease events based on self-reported hospitalizations with ICD-9 diagnoses of cancer, chronic kidney disease, pneumonia, deep venous thromboembolism/pulmonary embolism, chronic obstructive pulmonary disease, dementia, and hip fracturehard clinical
Improving cardiovascular health as measured by the Life's Simple 7 score is associated with a significantly reduced risk of multiple chronic nonvascular conditions, including cancer, chronic kidney disease, and COPD.
Cite This Study
Ogunmoroti et al. (2016) studied this question.