Advances in the Treatment of Acute Myelogenous Leukemia

ACUTE myelogenous leukemia is a neoplastic disease characterized by the proliferation of myeloblasts and other immature cells of the granulocytic series. Because of the common origin of several hematopoietic cell lines, abnormalities of proliferation or differentiation of monocytes, red-cell precursors and megakaryocytes are frequently present. The variability in the morphologic features of acute myelogenous leukemia has led to the development of several systems of classification. A recent and widely accepted system, that of the joint French-American-British committee, is based on the predominant cell type involved (Table 1). Three forms of acute myelogenous leukemia with granulocytic differentiation are identified: M-l, which . . .