Why the study?
Does secreted human lysyl-tRNA synthetase (KRS) induce a proinflammatory response in human monocytes/macrophages?
Does secreted human lysyl-tRNA synthetase (KRS) induce a proinflammatory response in human monocytes/macrophages?
Human lysyl-tRNA synthetase acts as a previously uncharacterized signaling molecule that induces an immune response by activating monocytes/macrophages.
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KRS may amplify TNF-α inflammation via monocytes; leaves open its role in cardiovascular disease pending in vivo studies.
Park et al. (2005) studied this question.
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