What question did this study set out to answer?

To identify the function of the newly discovered klotho gene and investigate its role in suppressing ageing phenotypes in vivo.

November 6, 1997

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

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Overview

Experimental study reveals premature ageing phenotypes in klotho-deficient mice, indicating that the klotho protein functions in a signalling pathway regulating systemic ageing.

Key Points

To identify the function of the newly discovered klotho gene and investigate its role in suppressing ageing phenotypes in vivo.
Generated and analyzed mouse models harboring defective klotho gene expression.
Characterized phenotypic traits across multiple organ systems and examined the amino acid sequence homology of the encoded klotho protein.
Mice with defective klotho expression developed a systemic syndrome mimicking human ageing, characterized by shortened lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis, and emphysema.
Sequence analysis identified klotho as a membrane protein with homology to beta-glucosidase enzymes, indicating its involvement in a systemic signalling pathway that modulates age-related morbidity.

Cite This Study

A 1997 study studied this question.

synapsesocial.com/papers/6a7c83398f37468f13e426ea https://doi.org/10.1038/36285

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November 6, 1997

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

View Full Paper

Ask AI

Bookmark

Discussion

Member takes

Overview

Experimental study reveals premature ageing phenotypes in klotho-deficient mice, indicating that the klotho protein functions in a signalling pathway regulating systemic ageing.

Key Points

To identify the function of the newly discovered klotho gene and investigate its role in suppressing ageing phenotypes in vivo.
Generated and analyzed mouse models harboring defective klotho gene expression.
Characterized phenotypic traits across multiple organ systems and examined the amino acid sequence homology of the encoded klotho protein.
Mice with defective klotho expression developed a systemic syndrome mimicking human ageing, characterized by shortened lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis, and emphysema.
Sequence analysis identified klotho as a membrane protein with homology to beta-glucosidase enzymes, indicating its involvement in a systemic signalling pathway that modulates age-related morbidity.

Cite This Study

A 1997 study studied this question.

synapsesocial.com/papers/6a7c83398f37468f13e426ea https://doi.org/10.1038/36285

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