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Key Points • Asciminib inhibits Abl2 (Abelson-related gene) by interacting with different myristate pocket residues when compared with Abl.• ABL2 exon 3–encoded region of the SH3 domain is critical for STAMP inhibitor activity against ABL2 rearrangements in vitro and in vivo.
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Lagonik et al. (2025) studied this question.
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