Why the study?
Do mice with an alpha-MHC403/+ mutation exhibit electrophysiological abnormalities and arrhythmias compared to wild-type mice?
Population
Mice harboring an alpha-myosin heavy chain Arg403Gln missense mutation modeling familial hypertrophic…
Comparison
In vivo cardiac electrophysiology testing vs Wild-type mice
Design
Preclinical
Authors
Loading...
Alpha-MHC403/+ mice model FHC electrophysiology; leaves open translation to human arrhythmia risk.
Do mice with an alpha-MHC403/+ mutation exhibit electrophysiological abnormalities and arrhythmias compared to wild-type mice?
The alpha-MHC403/+ mutation in mice causes distinct electrophysiologic abnormalities and inducible ventricular ectopy, validating a novel method to explore genotype-phenotype relationships in familial hypertrophic cardiomyopathy.
Berul et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: