Do mice with an alpha-MHC403/+ mutation exhibit electrophysiological abnormalities and arrhythmias compared to wild-type mice?
The alpha-MHC403/+ mutation in mice causes distinct electrophysiologic abnormalities and inducible ventricular ectopy, validating a novel method to explore genotype-phenotype relationships in familial hypertrophic cardiomyopathy.
A new mouse cardiac electrophysiology method was used to study mice harboring an alpha-myosin heavy chain Arg403Gln missense mutation (alpha-MHC403/+), which results in histological and hemodynamic abnormalities characteristic of familial hypertrophic cardiomyopathy (FHC) and sudden death of uncertain etiology during exercise. Wild-type animals had completely normal cardiac electrophysiology. In contrast, FHC mice demonstrated (a) electrocardiographic abnormalities including prolonged repolarization intervals and rightward axis; (b) electrophysiological abnormalities including heterogeneous ventricular conduction properties and prolonged sinus node recovery time; and (c) inducible ventricular ectopy. These data identify distinct electrophysiologic abnormalities in FHC mice with a specific alpha-myosin mutation, and also validate a novel method to explore in vivo the relationship between specific genotypes and their electrophysiologic phenotypes.
Berul et al. (Sat,) studied this question.
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