April 1, 1967Circulation
Relation of Body Weight to Development of Coronary Heart Disease
Why the study?
Does weight gain and obesity increase the risk of developing coronary heart disease in men and women?
Population
5,127 men and women followed for signs of initial development of coronary heart disease
Design
Cohort
Follow-up
12 years
Authors
Discussion
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Member takes
Implication
Weight gain may selectively raise angina and sudden death risk; leaves open causal effects on MI and intervention benefits in observational data.
Structured PICO
Does weight gain and obesity increase the risk of developing coronary heart disease in men and women?
P
Population
5,127 men and women followed for signs of initial development of coronary heart disease
I
Intervention
Antecedent relative weight, weight gain after age 25 years, and obesity
O
Outcome
Initial development of coronary heart disease (including angina pectoris, sudden death, and myocardial infarction)hard clinical
Obesity and weight gain independently increase the risk of angina pectoris and sudden death in men, whereas in women this risk is primarily observed when accompanied by elevated blood pressure and cholesterol.
Cite This Study
Kannel et al. (1967) studied this question.