Why the study?
Does thrombin receptor antisense sequence reduce smooth muscle cell proliferation in vitro?
Population
Vascular wall cells (smooth muscle cells) in vitro
Comparison
Antisense oligodeoxynucleotide to the rat… vs Sense, scrambled, and missense control…
Design
Preclinical
Follow-up
up to 6 days in culture
Authors
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Offers in vitro proof-of-concept for thrombin receptor antisense; leaves open in vivo efficacy against arterial injury responses.
Does thrombin receptor antisense sequence reduce smooth muscle cell proliferation in vitro?
Thrombin receptor-specific antisense sequences inhibit growth-related effects of serum and thrombin on smooth muscle cells in vitro, suggesting a potential strategy for limiting receptor-mediated arterial injury responses.
Chaikof et al. (1995) studied this question.
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