April 1, 1997Stroke
We Need Stronger Predictors of Major Vascular Events in Patients With a Recent Transient Ischemic Attack or Nondisabling Stroke
Why the study?
Does a prediction model based on clinical and demographic information reliably identify patients at high risk of recurrent major vascular events after a recent TIA or nondisabling stroke?
Population
3,127 patients within 3 months after onset of a transient ischemic attack, amaurosis fugax, or nondisabling…
Design
Cohort, double-blind (in the original trial)
Authors
Discussion
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Implication
Insufficient clinical-demographic models limit reliable high-risk identification post-TIA; leaves open integration of novel biomarkers for better stratification.
Structured PICO
Does a prediction model based on clinical and demographic information reliably identify patients at high risk of recurrent major vascular events after a recent TIA or nondisabling stroke?
P
Population
3,127 patients within 3 months after onset of a transient ischemic attack, amaurosis fugax, or nondisabling stroke
I
Intervention
Prediction model based on clinical and demographic information and ancillary investigations
O
Outcome
Composite outcomes of fatal or nonfatal stroke, and composite of myocardial infarction, stroke, or vascular deathcomposite
Existing clinical and demographic prognostic factors are insufficient to reliably identify patients at high risk of recurrent major vascular events after a TIA or nondisabling stroke.
Cite This Study
Dippel et al. (1997) studied this question.