Why the study?
Traditional Chinese medicine injections are widely used for anthracycline-induced cardiotoxicity, but the quality of published systematic reviews and meta-analyses is uneven, leaving their effectiveness and safety unclear.
Do Traditional Chinese medicine injections prevent or treat anthracyclines-induced cardiotoxicity?
Do Traditional Chinese medicine injections prevent or treat anthracyclines-induced cardiotoxicity?
Current systematic reviews and meta-analyses evaluating TCM injections for anthracycline-induced cardiotoxicity are of low methodological quality, highlighting the need for higher-quality evidence.
Low-quality reviews preclude TCM injection use for anthracycline cardiotoxicity; high-quality RCTs needed to clarify benefit.
INTRODUCTION: Traditional Chinese medicine (TCM) injections, as a relatively safe and low-cost treatment, have been widely used in the prevention and treatment of anthracyclines-induced cardiotoxicity in China. However, the quality of the relevant systematic reviews and meta-analyses published in recent years is uneven, so that the effectiveness and safety of TCM injections in preventing and treating anthracyclines-induced cardiotoxicity remain to be discussed. A systematic overview is therefore needed to provide a more advanced evidentiary reference for clinical practice. METHODS: Eight Chinese and English databases were searched by computer to screen the meta-analyses/systematic reviews on the efficacy of traditional Chinese medicine injections for the prevention and treatment of anthracyclines-induced cardiotoxicity from the database establishment to October 2022. The methodological quality and evidence quality of outcome indicators included in the study were evaluated by AMSTAR 2 tool, PRISMA statement and GRADE classification. RESULTS: A total of 7 articles were included in the study. The quality evaluation of AMSTAR 2 showed that 7 studies were extremely low-level; PRISMA stated that the evaluation results showed that the reports of 7 studies were of intermediate quality; The GRADE rating indicated that most of the evidence was of low quality. CONCLUSION: The methodological quality and evidence quality of meta-analysis/system evaluation concerning the prevention and treatment of anthracyclines-induced cardiotoxicity by Chinese medicine are currently low, and the effectiveness of Chinese medicine in the treatment of anthracyclines-induced cardiotoxicity needs more high-quality evidence-based evidence.
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Li et al. (2023) studied this question.
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