In human endometriotic tissue, elevated miR-451 modulates macrophage migration inhibitory factor and limits epithelial cell survival.
Elevated miR-451 may limit endometriotic cell survival; leaves open therapeutic targeting in human disease.
study question: What is the role of microRNA-451 (miR-451) in human endometriotic tissue? summary answer: miR451 expression was elevated in endometriotic lesion tissue. MiR451 modulated the expression of macrophage migration inhibitory factor and limited cell survival.
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Graham et al. (2015) studied this question.
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