What does this research mean for the field?

ACE inhibitor therapy in patients with chronic heart failure does not compromise and may provide small short-term improvements in health-related quality of life, though long-term benefits are often small or not significantly different from placebo. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 12, 1998Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Effects of ACE Inhibitor Therapy on Quality of Life in Patients with Heart Failure

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Why the study?

Does ACE inhibitor therapy improve quality of life in patients with chronic heart failure secondary to reduced left ventricular systolic function?

Population

Patients with chronic heart failure secondary to reduced left ventricular systolic function

Comparison

ACE inhibitors (including enalapril and ramipril) vs Placebo

Design

Review

Authors

EWEugene E. WolfelUniversity of Colorado Denver

Discussion

Member takes

Implication

Long-term HRQL benefits of ACE inhibitors in HFrEF remain uncertain; leaves open dedicated prospective QoL trials.

Structured PICO

Does ACE inhibitor therapy improve quality of life in patients with chronic heart failure secondary to reduced left ventricular systolic function?

Population

Patients with chronic heart failure secondary to reduced left ventricular systolic function

Intervention

ACE inhibitors (including enalapril and ramipril)

Comparator

Placebo

Outcome

Health-related quality of life (HRQL)patient reported

ACE inhibitors do not compromise and may improve certain components of quality of life in patients with chronic heart failure with reduced ejection fraction, alongside their known survival benefits.

Limitations

Confounded by a definite placebo effect
High noncompletion rates for sicker patients, particularly beyond 1 year
Measurement tools varied
Different quality of life domains were evaluated, making direct comparison problematic

Cite This Study

Eugene E. Wolfel (1998) studied this question.

synapsesocial.com/papers/6a1d3ef71c2cbcb15c5e00b4 https://doi.org/10.1002/j.1875-9114.1998.tb03155.x

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Effects of ACE Inhibitor Therapy on Quality of Life in Patients with Heart Failure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Effects of ACE Inhibitor Therapy on Quality of Life in Patients with Heart Failure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider