February 1, 1991AJP Heart and Circulatory Physiology
Contractile strength and mechanical efficiency of left ventricle are enhanced by physiological afterload
Population
Left ventricle model (specifics not provided in abstract)
Comparison
Ejecting contractions vs Isovolumic contractions
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Fiber shortening may augment LV contractility and efficiency in animals; leaves open translation to human disease.
Structured PICO
P
Population
Left ventricle model (specifics not provided in abstract)
I
Intervention
Ejecting contractions (physiological afterload allowing fiber shortening)
C
Comparator
Isovolumic contractions
O
Outcome
Metabolic cost (oxygen consumption, MVO2), mechanical efficiency (MVO2-PVA relation), and contractile strength (end-systolic pressure-volume relation slope, Ees)surrogate
Physiological afterload conditions that allow substantial fiber shortening increase the contractile strength and metabolic efficiency of the left ventricle.
Cite This Study
Burkhoff et al. (1991) studied this question.