What question did this study set out to answer?

To review the mechanisms through which protein kinase A regulates normal cardiac physiology, mediates disease pathogenesis, and serves as a potential therapeutic target.

January 8, 2021Cardiovascular ResearchOpen Access

Physiological and pathological roles of protein kinase A in the heart

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Why the study?

Dynamic control of PKA is essential for cardiac homeostasis, and dysregulation of PKA signalling is associated with a broad range of heart diseases.

Key Points

To review the mechanisms through which protein kinase A regulates normal cardiac physiology, mediates disease pathogenesis, and serves as a potential therapeutic target.
Synthesized molecular, physiological, and translational literature detailing cardiac protein kinase A (PKA) signaling.
Examined downstream effects of catecholamine-induced, cyclic AMP-dependent PKA activation across healthy and diseased myocardial models.
PKA activation via β-adrenergic signaling enhances intracellular calcium cycling and augments myocardial contractility to sustain cardiac homeostasis.
Both excessive activation and pathological inactivation of PKA contribute to diverse disorders, including myocardial ischemia, cardiac hypertrophy, heart failure, and diabetic or stress-induced cardiomyopathies.
Therapeutic cardioprotection requires disease-specific modulation, where selected phenotypes benefit from targeted PKA inhibition while others require PKA pathway activation.

Design

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Discussion

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Implication

PKA-targeted therapies merit preclinical development for cardioprotection; leaves open clinical translation pending selective agents and trials.

Cite This Study

Liu et al. (2021) studied this question.

synapsesocial.com/papers/6a1d41b933e2df9c962f3465 https://doi.org/10.1093/cvr/cvab008

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Implication

PKA-targeted therapies merit preclinical development for cardioprotection; leaves open clinical translation pending selective agents and trials.

Physiological and pathological roles of protein kinase A in the heart

Key Points

Discussion

Implication

Cite This Study

Physiological and pathological roles of protein kinase A in the heart

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider