What does this research mean for the field?

Titin's I-band/A-band junction is not required for thick filament length control, but its deletion increases strain on titin's spring elements, leading to diastolic dysfunction and symptoms of heart failure with preserved ejection fraction (HFpEF). Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

September 22, 2014Proceedings of the National Academy of SciencesOpen Access

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

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Population

Mouse model with genetically targeted deletion of 14 immunoglobulin-like and fibronectin type 3 domains…

Design

Preclinical

Authors

HGHenk GranzierHeart Failure & Transplant KHKirk R. HutchinsonUniversity of Arizona PTPaola ToninoUniversity of Arizona

Discussion

Member takes

Implication

Does not support clinical translation; leaves open titin modulation as HFpEF therapy.

Structured PICO

Population

Mouse model with genetically targeted deletion of 14 immunoglobulin-like and fibronectin type 3 domains comprising the I-band/A-band (IA) junction of titin

Intervention

Genetic deletion of the IA junction of titin

Outcome

Thick filament length, titin's molecular elasticity, and left ventricular chamber functionsurrogate

Deleting titin's IA junction in a mouse model reveals its critical role in biomechanical sensing and demonstrates that increased strain on titin's spring elements causes diastolic dysfunction and HFpEF.

Cite This Study

Granzier et al. (2014) studied this question.

synapsesocial.com/papers/6a1d41bb33e2df9c962f3471 https://doi.org/10.1073/pnas.1411493111

Topics

Echocardiography

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September 22, 2014Proceedings of the National Academy of SciencesOpen Access

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

View Full Paper

Ask AI

Bookmark

Population

Mouse model with genetically targeted deletion of 14 immunoglobulin-like and fibronectin type 3 domains…

Design

Preclinical

Authors

HGHenk GranzierHeart Failure & Transplant KHKirk R. HutchinsonUniversity of Arizona PTPaola ToninoUniversity of Arizona

Discussion

Member takes

Implication

Does not support clinical translation; leaves open titin modulation as HFpEF therapy.

Structured PICO

Population

Mouse model with genetically targeted deletion of 14 immunoglobulin-like and fibronectin type 3 domains comprising the I-band/A-band (IA) junction of titin

Intervention

Genetic deletion of the IA junction of titin

Outcome

Thick filament length, titin's molecular elasticity, and left ventricular chamber functionsurrogate

Cite This Study

Granzier et al. (2014) studied this question.

synapsesocial.com/papers/6a1d41bb33e2df9c962f3471 https://doi.org/10.1073/pnas.1411493111

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Echocardiography

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