Why the study?
Does transverse aortic constriction-induced heart failure alter titin-based passive myocardial stiffness in mice?
Does transverse aortic constriction-induced heart failure alter titin-based passive myocardial stiffness in mice?
Transverse aortic constriction-induced heart failure in mice increases passive myocardial stiffness primarily through hyperphosphorylation of titin spring elements, offsetting the compliance gained from titin splicing changes.
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Animal data implicate titin hyperphosphorylation in HF stiffness; leaves open human relevance and therapeutic targeting.
Hudson et al. (2011) studied this question.
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