Why the study?
Does exposure to carbon dioxide and other vasoactive substances alter arterial pressure and vascular reactivity differently in normal versus hypertensive dogs?
Population
"Normal" and hypertensive dogs, including sympathectomized animals
Comparison
Exposure to respiratory gas mixtures and other… vs Normal dogs vs. renal experimental hypertensive…
Design
Preclinical
Authors
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Distinguishes vascular reactivity by hypertension etiology in canine models; leaves open human translation.
Does exposure to carbon dioxide and other vasoactive substances alter arterial pressure and vascular reactivity differently in normal versus hypertensive dogs?
Neurogenic and renal experimental hypertension in dogs exhibit different vascular reactivity to carbon dioxide, with neurogenic hypertensives showing heightened depressor responses.
Page et al. (1951) studied this question.