Key result
Angiotensin II-receptor blockers demonstrated a lower incidence of cough compared to ACE inhibitors across 10 comparative trials, with absent or rare angioedema similar to placebo.
Why the study?
Do angiotensin II-receptor blockers reduce the incidence of cough and angioedema compared to ACE inhibitors in patients with hypertension?
Population
Patients in published placebo-controlled and comparative trials, primarily treated for hypertension
Comparison
Angiotensin II (AII)-receptor blockers vs Angiotensin-converting enzyme inhibitors and…
Design
Review
Authors
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ARBs may be preferred over ACEIs to reduce cough risk; leaves open whether this improves adherence or outcomes in hypertension.
Systematic Review
Do angiotensin II-receptor blockers reduce the incidence of cough and angioedema compared to ACE inhibitors in patients with hypertension?
Angiotensin II receptor blockers are as effective as ACE inhibitors for hypertension but have a significantly better tolerability profile regarding cough and angioedema.
George Pylypchuk (1998) conducted a systematic review in Hypertension. Angiotensin II (AII)-receptor blockers vs. ACE inhibitors was evaluated on Incidence of cough and angioedema. Angiotensin II-receptor blockers demonstrated a lower incidence of cough compared to ACE inhibitors across 10 comparative trials, with absent or rare angioedema similar to placebo.
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