Key result
Improving glucose oxidation and reducing epicardial fat may enhance myocardial efficiency and slow CVD progression.
Why the study?
This review aims to explain myocardial energy substrate adaptation, oxidative metabolism reduction and epicardial fat accumulation in pathological states, and potential therapeutic targets.
Design
Review
Authors
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Hypothesis-generating for metabolic therapies targeting epicardial fat; leaves open clinical efficacy in prospective trials.
Therapies targeting epicardial fat volume and inflammation may improve myocardial oxidative metabolism and reduce cardiovascular disease progression by mitigating lipotoxicity and insulin resistance.
Gandoy-Fieiras et al. (2020) conducted a review in Cardiovascular disease and metabolic disorders. Metabolic therapies (e.g., SGLT2 inhibitors, GLP-1 agonists, trimetazidine) was evaluated. Therapies that improve glucose oxidative metabolism and reduce epicardial fat accumulation may enhance myocardial energy efficiency and reduce cardiovascular disease progression.
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