What does this research mean for the field?

In contracting cardiac myocytes, electrostimulation-induced cellular contraction increases long-chain fatty acid uptake specifically by enhancing flux through the FAT/CD36 transporter. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 2001AJP Endocrinology and Metabolism

Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes

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Structured PICO

Population

Isolated rat cardiac myocytes in suspension

Intervention

Electrostimulation (200 V, 4 Hz)

Comparator

Quiescent myocytes (no electrostimulation)

Outcome

Palmitate uptake (measured after 3-min incubation) and oxidation (measured after 30 min)surrogate

In contracting cardiac myocytes, palmitate uptake is increased due to enhanced flux through FAT/CD36.

Authors

JLJoost J.F.P. LuikenHeart Failure / Cardiomyopathy JWJodil WillemsMaastricht University GVGer J. VusseGeneral / Preventive / Lipids

Discussion

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Implication

Supports contraction-stimulated fatty acid uptake via FAT/CD36 in myocytes; hypothesis-generating for human cardiac metabolic therapies.

Cite This Study

Luiken et al. (2001) studied this question.

synapsesocial.com/papers/6a1d523a33e2df9c962f516b https://doi.org/10.1152/ajpendo.2001.281.4.e704

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Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes

Structured PICO

Discussion

Implication

Cite This Study

Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider