CD8+ T cell responses recognizing immunodominant Chlamydia antigens fail to protect against infection

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CD8+ T cell responses targeting immunodominant Chlamydia antigens fail to provide protection against Chlamydia trachomatis infection. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Safia Guleed; Nina Dieu Nhien Tran Nguyen; Sharmila Subratheepam; Kristoffer Mazanti Melchiors; Anja Weinreich Olsen; Matías Ciancaglini; Anna Lena Kastner; Emanuele Nolfi; Daniel Pinschewer; Frank Follmann; Jan Pravsgaard Christensen; Alice J.A.M. Sijts; Jes Dietrich

doi:10.1016/j.isci.2026.115242

March 5, 2026iScienceOpen Access

CD8+ T cell responses recognizing immunodominant Chlamydia antigens fail to protect against infection

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Abstract

T cells play a minor or no role in protection against C.t.

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Guleed et al. (2026) studied this question.

synapsesocial.com/papers/6a1d55df5b7fddc3520525d6 https://doi.org/10.1016/j.isci.2026.115242

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CD8+ T cell responses recognizing immunodominant Chlamydia antigens fail to protect against infection

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CD8+ T cell responses recognizing immunodominant Chlamydia antigens fail to protect against infection

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