Key result
In patients with white coat hypertension, the non-dipper pattern was associated with a significantly higher index of cardiac electrophysiological balance with heart rate correction (ICEBc) compared to the dipper pattern (5.09 vs 4.78, p=0.001).
Why the study?
Non-dipper and prehypertensive patterns are linked to ventricular arrhythmias, and white coat hypertension causes target organ damage, but the effect of dipper versus non-dipper patterns on the index of cardiac electrophysiological balance in white coat hypertension was unknown.
Does a non-dipper blood pressure pattern increase the index of cardiac electrophysiological balance (ICEB) in patients with white coat hypertension?
Observational (n=108)
No
Does a non-dipper blood pressure pattern increase the index of cardiac electrophysiological balance (ICEB) in patients with white coat hypertension?
Absolute Event Rate: 5.09% vs 4.78%
p-value: p=0.001
In patients with white coat hypertension, a non-dipper blood pressure pattern is associated with a higher heart rate-corrected index of cardiac electrophysiological balance (ICEBc), suggesting a potential increased susceptibility to ventricular arrhythmias.
Non-dipper pattern may signal higher arrhythmia susceptibility in white coat hypertension; leaves open prospective validation of ICEBc.
Aim: The index of cardiac electrophysiological balance (ICEB) is a new marker that can show the potential for ventricular arrhythmia and indicate the balancebetween ventricular depolarization and repolarization. A tendency toward ventricular arrhythmia has been shown innon-dipper hypertension and prehypertensive patients in various studies. White coat hypertension (WCH) has been shown to be associated with target organ damage and the actual development of hypertension. In this study, we aimed to evaluate the effect of dipper and non-dipper patterns on the ICEB in patients diagnosed with WCH. Material and Method: A total of 108 patients were included in this study. Patients were divided into two groups as dipper and non-dipper patterns according to ABPM. QT/QRS (ICEB) and cQT/QRS (ICEBc) were recorded with computerized interpretation of the electrocardiogram. Results: While electrocardiographic parameters including heart rate, PR interval, QT interval, cQT interval, and ICEB were similar in both groups (p>.05), in the non-dipper group, QRS duration was lower (p=.017) and ICEBc was higher (p=.001). Conclusion: ICEBc may predict asusceptibility to ventricular arrhythmias in WCH patients. Therefore, non-dipper WCH patients with a high ICEBc should be followed for arrhythmia outcomes in addition to hypertensive outcomes.
No takes yet. Share an insight, caveat, or question.
Karamanlıoğlu et al. (2022) conducted an observational in White coat hypertension (n=108). Non-dipper pattern vs. Dipper pattern was evaluated on Index of cardiac electrophysiological balance with heart rate correction (ICEBc) (p=0.001). In patients with white coat hypertension, the non-dipper pattern was associated with a significantly higher index of cardiac electrophysiological balance with heart rate correction (ICEBc) compared to the dipper pattern (5.09 vs 4.78, p=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: