Resting heart rate ≥80 bpm (vs 60-69 bpm) was associated with an increased risk of dementia (HR 1.55; 95% CI 1.06-2.27) and faster cognitive decline, independent of cardiovascular disease.
Cohort (n=2,147)
Does a higher resting heart rate (≥80 bpm) increase the risk of dementia and cognitive decline in older adults compared to a resting heart rate of 60-69 bpm?
Higher resting heart rate (≥80 bpm) is associated with an increased risk of dementia and faster cognitive decline in older adults, independent of cardiovascular disease.
Effect estimate: HR 1.55 (95% CI 1.06-2.27)
INTRODUCTION: Resting heart rate (RHR) predicts future risk for cardiovascular disease (CVD). However, longitudinal studies investigating the relationship of RHR with cognitive decline are scarce. METHODS: This population-based cohort study included 2147 participants (age≥60) in SNAC-K who were free of dementia and regularly followed from 2001-2004 to 2013-2016. RHR was assessed with electrocardiogram. Dementia was diagnosed following the Diagnostic and Statistical Manual of Mental Disorders 4th Revision criteria. Global cognitive function was assessed using Mini-Mental State Examination (MMSE). Data were analyzed using Cox and linear mixed-effects models. RESULTS: RHR≥80 (vs. 60-69) bpm was associated with a multi-adjusted hazard ratio of 1.55 (95% confidence interval 1.06-2.27) for dementia. The association remained significant after excluding participants with prevalent and incident CVDs. Similarly, RHR≥80 bpm was associated with a multi-adjusted β-coefficient of -0.13 (-0.21 to -0.04) for MMSE score. DISCUSSION: Higher RHR is associated with increased risk for dementia and faster cognitive decline independent of CVDs in a general population of elderly people.
Imahori et al. (Fri,) conducted a cohort in Dementia and cognitive decline (n=2,147). Resting heart rate ≥80 bpm vs. Resting heart rate 60-69 bpm was evaluated on Dementia (HR 1.55, 95% CI 1.06-2.27). Resting heart rate ≥80 bpm (vs 60-69 bpm) was associated with an increased risk of dementia (HR 1.55; 95% CI 1.06-2.27) and faster cognitive decline, independent of cardiovascular disease.