Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2022Journal of Clinical NeurologyOpen Access

Resting Heart Rate and Cognitive Decline: A Meta-Analysis of Prospective Cohort Studies

View Full Paper
Ask AI
Bookmark
Share

Key result

Increased resting heart rate linked to ~18% higher risk of cognitive decline.

  • RR 1.18
  • 95% CI 1.04-1.33
  • n=53,621

Why the study?

While prior meta-analyses linked cognitive decline with heart rate variability, the impact of increased resting heart rate on incident cognitive decline remained to be evaluated.

Does increased resting heart rate increase the risk of cognitive decline and dementia?

Population

53,621 participants across 7 prospective cohort studies

Comparison

Increased resting heart rate vs lower resting heart rate

Design

Systematic review and meta-analysis of prospective cohort studies

Authors

HKHong-Bae KimDongseo UniversityYJYoung Hee JungHallym UniversityHHHyun Jeong HanMyongji Hospital

Discussion

Loading...

Member takes

Implication

Supports RHR monitoring for cognitive risk stratification; leaves open causality and need for interventional trials.

Study Design

Type

Meta-Analysis (n=53,621)

Structured PICO

Does increased resting heart rate increase the risk of cognitive decline and dementia?

P
Population
53,621 participants from 7 prospective cohort studies
I
Intervention
Increased resting heart rate (RHR)
C
Comparator
Lower resting heart rate
O
Outcome
Incidence of cognitive decline, including dementiahard clinical

Main Result

Effect estimate: RR 1.18 (95% CI 1.04-1.33)

Higher resting heart rate is associated with an increased risk of cognitive decline and dementia, suggesting a potential link between autonomic nerve activity and cognitive health.

Limitations

  • Small number of available prospective cohort studies and relatively small patient sample.
  • High heterogeneity was found in the primary analysis and most subgroup analyses.
  • Most studies assessed RHR only once at baseline and once during the follow-up period.
  • Several pivotal factors related to RHR and cognitive decline (e.g., anxiety, stress, medications) were not adjusted for.
  • Publication bias was identified.
  • publication bias
  • high heterogeneity

Cite This Study

Kim et al. (2022) conducted a meta-analysis in Cognitive decline and dementia (n=53,621). Increased resting heart rate vs. Lower resting heart rate was evaluated on Incidence of cognitive decline, including dementia (RR 1.18, 95% CI 1.04-1.33). Increased resting heart rate was significantly associated with a higher risk of cognitive decline (RR 1.18).

synapsesocial.com/papers/6a162c10599ca9964c8e90abhttps://doi.org/10.3988/jcn.2022.18.6.619
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heart Rate Variability Indexes in Dementia: A Systematic Review with a Quantitative Analysis2017 · 76 citations
  2. 2Association of Resting Heart Rate and Blood Pressure in Late Adolescence With Subsequent Mental Disorders2016 · 85 citations
  3. 3Heart Rate Variability, Prefrontal Neural Function, and Cognitive Performance: The Neurovisceral Integration Perspective on Self-regulation, Adaptation, and Health2009 · 1,902 citations
  4. 4Increased Sympathetic and Decreased Parasympathetic Cardiac Innervation in Patients With Alzheimer's Disease1992 · 95 citations
  5. 5Association of resting heart rate with cognitive decline and dementia in older adults: A population‐based cohort study2021 · 47 citations