What question did this study set out to answer?

Synthesize recent evidence from neuropathology, neuroimaging, and animal models to re-evaluate the complex pathogenic mechanisms driving multiple sclerosis.

June 1, 2001Current Opinion in Neurology

Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment

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Authors

CLClaudia F. LucchinettiNorthwestern University WBWolfgang BrückNorthwestern University JNJohn H. NoseworthyMayo Clinic

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Implication

Review uncovers multifaceted lesion formation mechanisms in multiple sclerosis patients, highlighting why individuals exhibit variable responses to immunomodulatory treatments.

Key Points

Synthesize recent evidence from neuropathology, neuroimaging, and animal models to re-evaluate the complex pathogenic mechanisms driving multiple sclerosis.
Evaluated experimental findings from various animal models of inflammatory demyelinating disease.
Examined detailed pathological tissue analyses and magnetic resonance imaging studies of patients with multiple sclerosis.
Lesion formation in multiple sclerosis involves complex cellular pathways extending beyond purely T-cell-mediated mechanisms.
The diverse and complex underlying pathology directly corresponds to variable patient responses to immunomodulatory therapy.

Cite This Study

Lucchinetti et al. (2001) studied this question.

synapsesocial.com/papers/6a1d573b5a0c5c56ea04dc2b https://doi.org/10.1097/00019052-200106000-00002

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Implication

Review uncovers multifaceted lesion formation mechanisms in multiple sclerosis patients, highlighting why individuals exhibit variable responses to immunomodulatory treatments.

Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

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