We present here the construction of a DNA biosensor based on a tubular micromotor that only produces motion-based signal in the presence of DNA target. This "turn on" characteristic of the sensor is achieved by the addition of Pt nanoparticle-DNA conjugate as the motion-inducing catalyst for the micromotors through DNA hybridization. Our work potentially offers new design strategies for motion-based biosensors with higher specificity.
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Nguyen et al. (2015) studied this question.
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