Key result
Obesity was associated with a significant decrease in the peak rotation of the left ventricular apex compared to normal-weight controls (3.81 vs. 5.77 degrees, P<0.001).
Why the study?
Does obesity alter left ventricular rotation, twist, and torsion as measured by velocity vector imaging compared to normal weight subjects?
Observational (n=60)
Does obesity alter left ventricular rotation, twist, and torsion as measured by velocity vector imaging compared to normal weight subjects?
Answers are grounded in this paper and cite their sources.
Obesity is associated with decreased peak rotation of the left ventricle apex, suggesting early subclinical LV dysfunction detectable by velocity vector imaging.
AIMS: Obesity is a well-known risk factor in the development of cardiovascular disease. We hypothesize that early left ventricular (LV) dysfunction secondary to obesity could be signalled by abnormal LV rotation. METHODS AND RESULTS: This prospective study examined 60 subjects divided into two groups: obese group with body mass index (BMI) >or=30 and control group with BMI <25. The peak rotation, twist, and torsion of the left ventricle were studied in obese and control subjects, using velocity vector imaging. Age and gender were comparable between the two groups. Obese subjects had higher BMI, waist circumference, fasting glucose, triglycerides, systolic and diastolic blood pressure, low-density lipoprotein cholesterol, and lower high-density lipoprotein cholesterol (P < 0.05). In obese subjects, LV mass and LV mass index were increased, and the ratio of mitral early and late diastolic filling velocity was decreased (P < 0.05). In obese subjects, the peak twist and torsion of the left ventricle displayed a lower trend, and the peak rotation of the left ventricle apex decreased significantly (3.81 +/- 2.09 degrees vs. 5.77 +/- 3.27 degrees , P < 0.001). CONCLUSION: Obesity was associated with changes in LV rotation. Velocity vector imaging is a feasible and reproducible echocardiographic technique for the detection of early subclinical LV dysfunction.
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Deng et al. (2010) conducted an observational in Obesity (n=60). Obesity (BMI ≥30) vs. Control (BMI <25) was evaluated on Peak rotation of the left ventricle apex (p=<0.001). Obesity was associated with a significant decrease in the peak rotation of the left ventricular apex compared to normal-weight controls (3.81 vs. 5.77 degrees, P<0.001).
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