Key result
Long-term fatty-fish consumption linked to ~54% lower risk of sudden coronary death.
Why the study?
The relationship between long-term fish consumption or EPA+DHA intake from fish and (sudden) coronary death was not fully established.
Does long-term fish consumption and EPA+DHA intake reduce (sudden) coronary heart disease death in men?
Cohort (n=1,373)
Does long-term fish consumption and EPA+DHA intake reduce (sudden) coronary heart disease death in men?
Hazard Ratio: 0.46 (95% CI 0.27–0.78)
Long-term fatty-fish consumption is associated with a reduced risk of sudden coronary death in men, though the protective effect against overall CHD death attenuates with age.
Fatty-fish intake was associated with lower sudden coronary death risk; leaves open whether long-term consumption confers benefit in contemporary cohorts.
AIMS: To assess the relationship between fish consumption or eicosapentaenoic acid (EPA)+docosahexaenoic acid (DHA) intake from fish, and (sudden) coronary death. METHODS AND RESULTS: The impact of recent and long-term fish consumption and EPA+DHA intake on (sudden) coronary death was investigated in the Zutphen Study, a cohort of 1373 men born between 1900 and 1920, and examined repeatedly between 1960 and 2000. Hazard ratios were obtained from time-dependent Cox regression models. The associations between long-term fish consumption, EPA+DHA intake, and (sudden) coronary death were stronger than those of recent consumption. Long-term fish consumption was inversely associated (borderline significant) with coronary heart disease (CHD) death; however, the strength of the association decreased from age 50 [HR: 0.32 (95% CI: 0.13-0.80)] until age 80 [HR: 1.34 (0.58-3.12)]. For men with a daily EPA+DHA intake from fish below 250 mg compared with no intake, CHD death risk was reduced to the same extent as for men with a daily intake above 250 mg (P-value for trend: 0.27). Moreover, long-term fatty-fish consumption lowered the risk of sudden coronary death [HR: 0.46 (0.27-0.78)]. CONCLUSION: The strength of the association between long-term fish consumption and CHD death decreased with increasing age. Fatty-fish consumption lowered sudden coronary death risk. There was no clear dose-response relationship between EPA+DHA intake and (sudden) coronary death.
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Streppel et al. (2008) reported a cohort. Long-term fatty-fish consumption vs. No or lower intake was evaluated on Sudden coronary death (HR 0.46, 95% CI 0.27-0.78). Long-term fatty-fish consumption lowered the risk of sudden coronary death (HR 0.46; 95% CI 0.27-0.78), while the association with overall CHD death decreased with increasing age.
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