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Determines cerebrovascular permeability to nonelectrolyte tracers across distinct brain regions in conscious rats, establishing baseline limits of blood-brain barrier restriction.
I&c*. 2hyCL $3): H299-~3~1j 1978. -Vascular permeability P in different cerebral regions of the conscious rat was determined, independently of blood flow, for "C tracers of glycerol, mannitol, sucrose, and inulin. A tracer was injected intravenously, arterial plasma concentrations were monitored, and regional brain concentrations were measured at specific times thereafter.
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Ohno et al. (1978) studied this question.
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