Key result
Highest vs lowest quintile of EPA in adipose tissue was associated with a 45% lower risk of incident atrial fibrillation in men (HR 0.55; 95% CI 0.41-0.69) and women (HR 0.55; 95% CI 0.41-0.72).
Why the study?
The study was designed to examine the relation between adipose tissue content of EPA and DHA and the risk of incident AF.
Does higher adipose tissue content of EPA and DHA reduce the risk of incident atrial fibrillation?
Cohort (n=8,695)
Does higher adipose tissue content of EPA and DHA reduce the risk of incident atrial fibrillation?
Answers are grounded in this paper and cite their sources.
Higher adipose tissue content of EPA is associated with a significantly lower risk of incident atrial fibrillation in both men and women, while higher DHA is associated with lower risk only in women.
BACKGROUND: The aim of the present study was to examine the relation between adipose tissue content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the risk of incident atrial fibrillation (AF). METHODS: In this case-cohort study based on data from the Danish Diet, Cancer and Health cohort, a total of 5255 incident cases of AF was identified during 16.9 years of follow-up. Adipose tissue biopsies collected at baseline from all cases and from a randomly drawn subcohort of 3440 participants were determined by gas chromatography. Data were analysed using weighted Cox regression. RESULTS: Data were available for 4741 incident cases of AF (2920 men and 1821 women). Participants in the highest vs. the lowest quintile of EPA experienced a 45% lower risk of AF (men HR 0.55 (95% CI 0.41-0.69); women HR 0.55 (0.41-0.72)). For DHA, no clear association was found in men, whereas in women, participants in the highest quintile of DHA in adipose tissue had a 30% lower risk of incident AF (HR 0.70 (0.54-0.91)) compared to participants in the lowest quintile. CONCLUSIONS: A monotonous inverse association was found for the content of EPA in adipose tissue and risk of AF in both men and women. The content of DHA was inversely associated with the risk of AF in women, whereas no clear association was found for men.
No takes yet. Share an insight, caveat, or question.
Rix et al. (2021) conducted a cohort in Atrial fibrillation (n=8,695). Adipose tissue content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) vs. Lowest quintile of EPA/DHA was evaluated on Incident atrial fibrillation (AF) (HR 0.55, 95% CI 0.41-0.69). Highest vs lowest quintile of EPA in adipose tissue was associated with a 45% lower risk of incident atrial fibrillation in men (HR 0.55; 95% CI 0.41-0.69) and women (HR 0.55; 95% CI 0.41-0.72).
Synapse has enriched 10 related papers. Consider them for comparative context: