Key result
Long-term dietary intake of fish and n-3 polyunsaturated fatty acids was not significantly associated with a lower risk of atrial fibrillation (RR 1.01 and RR 1.03, respectively).
Why the study?
Does high dietary intake of fish or long-chain n-3 PUFAs reduce the risk of atrial fibrillation?
Meta-Analysis (n=206,811)
Does high dietary intake of fish or long-chain n-3 PUFAs reduce the risk of atrial fibrillation?
Answers are grounded in this paper and cite their sources.
Long-term dietary intake of fish or n-3 PUFAs is not significantly associated with a lower risk of atrial fibrillation.
Findings on the association between long-term intake of fish or long-chain n-3 polyunsaturated fatty acids (PUFAs) and risk of atrial fibrillation (AF) are inconsistent in observational studies. We conducted a meta-analysis of prospective studies to separately examine the associations between fish consumption and dietary intake of n-3 PUFAs with the risk of AF. A systematic search was conducted in PubMed and Embase to identify relevant studies. Risk estimates were combined using a random-effect model. Seven prospective cohort studies covering 206,811 participants and 12,913 AF cases were eligible. The summary relative risk of AF for the highest vs. lowest category of fish consumption and dietary intake of n-3 PUFAs was 1.01(95% confidence interval: 0.94–1.09) and 1.03 (95% confidence interval: 0.97–1.09), respectively. These null associations persisted in subgroup and dose-response analyses. There was little evidence of publication bias. This meta-analysis suggests that neither long-term intake of fish, nor of n-3 PUFAs were significantly associated with lower risk of AF.
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Li et al. (2017) conducted a meta-analysis in Atrial Fibrillation (n=206,811). Dietary fish consumption and n-3 PUFAs intake vs. Lowest category of fish consumption and dietary intake of n-3 PUFAs was evaluated on Risk of Atrial Fibrillation (AF) (RR 1.01, 95% CI 0.94-1.09). Long-term dietary intake of fish and n-3 polyunsaturated fatty acids was not significantly associated with a lower risk of atrial fibrillation (RR 1.01 and RR 1.03, respectively).
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