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BACKGROUND: Overexpression of cyclooxygenase-2 (COX-2) has been associated with hepatocellular carcinoma (HCC). Selective inhibition of COX-2 can come forward as improved and targeted therapeutic strategy. METHODS: cell, conjugated GNRs were exposed to continuous NIR laser irradiation near the resonance wavelength of GNRs (808 nm) for controlled release of oligos. RESULTS: < 0.05). Significant reduction in prostaglandin E2(PGE2) levels after LORONS treatment was also observed. Gene silencing efficacy using GNRs conjugated oligos without laser exposure was recorded 38%. CONCLUSION: We hereby conclude LORONS as a useful therapeutic strategy for localized gene silencing by remote optical excitation at desired intracellular location.
Awan et al. (Sat,) studied this question.