Key result
Higher soluble (pro)renin receptor levels link to increased relative wall thickness and reduced LVEF in young whites.
Why the study?
The study aimed to compare soluble (pro)renin receptor levels between black and white adults and explore associations of left ventricular structure and function with s(P)RR.
Cross-Sectional (n=1,172)
No
Effect estimate: β = 0.141
p-value: p=0.005
Higher soluble (pro)renin receptor levels are associated with adverse left ventricular remodeling and poorer systolic function in healthy young white adults, but not in black adults.
This study aims to compare soluble (pro)renin receptor [s(P)RR] levels between black and white adults and to explore the associations of left ventricular (LV) structure and function with s(P)RR in the total and ethnicity-stratified groups. The study sample included 1172 apparently healthy black (n = 587) and white (n = 585) participants of the African-PREDICT study aged 20−30 years. Echocardiography was performed to determine relative wall thickness (RWT), LV mass index, LV ejection fraction and stroke volume index (SVi). s(P)RR was analyzed from serum samples, while plasma renin activity-surrogate (PRA-S) and eq angiotensin II were determined using the RAS™ Fingerprint. s(P)RR was higher in the white participants compared to the black participants (p < 0.001). In multivariable-adjusted linear regression analyses, we observed a positive association between RWT and s(P)RR (β = 0.141; p = 0.005) and negative associations of LV ejection fraction (β = −0.123; p = 0.016) and SVi (β = −0.144; p = 0.004) with s(P)RR only in white adults. Higher s(P)RR observed in white vs. black participants was associated with higher RWT and poorer LV function only in young white adults but not in their black counterparts. These results suggest that s(P)RR may contribute to LV remodeling and dysfunction in white populations due to its role in volume−pressure regulation and its proinflammatory as well as profibrotic effects.
No takes yet. Share an insight, caveat, or question.
Gafane‐Matemane et al. (2022) conducted a cross-sectional in Healthy (n=1,172). Soluble (pro)renin receptor [s(P)RR] vs. Lower s(P)RR levels / Black participants was evaluated on Association between s(P)RR and relative wall thickness in white adults (β = 0.141, p=0.005). Higher soluble (pro)renin receptor levels were positively associated with relative wall thickness (β = 0.141) and negatively associated with left ventricular ejection fraction only in young white adults.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: