Key points are not available for this paper at this time.
To the Editor:— Orally given methyltestosterone has been used in clinical practice since its introduction by Foss in 1939 (Brit. M. J.2:11, 1939) both for its anabolic and for its androgen effects. It was not until 1947 that Werner (Am. J. Med.3:52, 1947) suggested that its use might rarely be associated with jaundice. Other reports followed (Kinsell, L. W.:Gastroenterology11:672, 1948; Werner, S. C.; Hanger, F. M.; and Kritzler, R. A.:Am. J. Med.8:325, 1950; Wood, J. C.:J. A. M. A.150:1484-1486 Dec. 13 1952; Van Dommelen, C. K. V., and Van der Steur, J. C.:Nederl. tijdschr. geneesk.99:2732, 1955; Brick, I. B., and Kyle, L. H.:New England J. Med.246:176, 1952). According to Werner and co-workers (ibid.) the whole picture of jaundice associated with methyltestosterone seems to be due to bile stasis. Biopsy showed dilated
Samantha Simpson (Sat,) studied this question.