Key result
High LIPG expression in lung adenocarcinoma tissues was significantly associated with poor overall survival and correlated with immune infiltrates and lipid metabolism.
Why the study?
Existing lung adenocarcinoma biomarkers lack satisfactory specificity and sensitivity, and the role of endothelial lipase gene (LIPG) in lung adenocarcinoma remains unclear.
Observational (n=142)
No
LIPG is highly expressed in lung adenocarcinoma and is associated with poor overall survival and altered immune cell infiltration, suggesting its potential as a prognostic biomarker.
Answers are grounded in this paper and cite their sources.
May inform prognosis in lung adenocarcinoma but should not change practice; hypothesis-generating for LIPG biomarker and target validation.
BACKGROUND: Although many biomarkers for lung adenocarcinoma (LUAD) have been identified, their specificity and sensitivity remain unsatisfactory. Endothelial lipase gene (LIPG) plays an important role in a variety of cancers, but its role in lung adenocarcinoma remains unclear. METHODS: TCGA, GEO, K-M plotter, CIBERSORT, GSEA, HPA, and GDSC were used to analyze LIPG in LUAD. Data analysis was mainly achieved by R 4.0.3. RESULTS: The expression of LIPG in LUAD tissues was higher than that in adjacent normal tissues, especially in women, patients aged >65 years, and those with lymph node metastasis. High expression predicted a poor prognosis. The results of enrichment analysis suggest that LIPG may exert profound effects on the development of LUAD through multiple stages of lipid metabolism and immune system regulation. In addition, LIPG expression was significantly correlated with the expression levels of multiple immune checkpoint genes and the abundance of multiple immune infiltrates, including the activated memory CD4 T cell, M1 macrophage, neutrophil, plasma cells, and T follicular helper (Tfh) cells in the LUAD microenvironment content. At the same time, patients with high LIPG expression respond well to a variety of antitumor drugs and have a low rate of drug resistance. CONCLUSIONS: LIPG is a prognostic marker and is associated with lipid metabolism and immune infiltration in LUAD.
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Wang et al. (2022) conducted an observational in Lung adenocarcinoma (n=142). High LIPG expression vs. Low LIPG expression was evaluated on Overall survival (p=0.048). High LIPG expression in lung adenocarcinoma tissues was significantly associated with poor overall survival and correlated with immune infiltrates and lipid metabolism.
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