June 1, 1987AJP Heart and Circulatory Physiology
Contractile responses to sympathetic activation after coronary instrumentation
Why the study?
Does acute coronary dissection or chronic coronary instrumentation alter contractile responses to sympathetic activation in dogs?
Population
19 dogs (7 anesthetized for acute dissection, 12 conscious for chronic instrumentation)
Comparison
Acute dissection of the left circumflex or left… vs Responses in different myocardial regions or…
Design
Preclinical
Follow-up
1 and 3 weeks (for chronic instrumentation)
Authors
Discussion
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Implication
Warrants caution interpreting regional sympathetic responses in instrumented canine models; leaves open human translation.
Structured PICO
Does acute coronary dissection or chronic coronary instrumentation alter contractile responses to sympathetic activation in dogs?
P
Population
19 dogs (7 anesthetized for acute dissection, 12 conscious for chronic instrumentation)
I
Intervention
Acute dissection of the left circumflex (CX) or left anterior descending (LAD) coronary artery, and chronic instrumentation of the CX or LAD
C
Comparator
Responses in different myocardial regions (anterior vs posterior wall) or pre-instrumentation baseline
O
Outcome
Contractile responses (systolic shortening velocity and thickening velocities) to sympathetic activation (nerve stimulation or caval occlusion)surrogate
Coronary instrumentation and acute dissection of the LAD, but not the CX, can produce regional sympathetic denervation in a canine model.
Cite This Study
Heusch et al. (1987) studied this question.