What does this research mean for the field?

Patients' preferences for the benefits and risks of anticoagulant therapy vary significantly, with fatal bleeding being the most heavily weighted risk, and these preferences are strongly influenced by previous experiences with myocardial infarction or stroke. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 2014Circulation Cardiovascular Quality and Outcomes

Patients’ Preferences in Anticoagulant Therapy

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Why the study?

How do patients with cardiovascular disease weigh the relative benefits and risks of anticoagulant therapy?

Population

341 US patients with cardiovascular disease from an online panel

Design

Cross-sectional

Authors

MNMehdi NajafzadehMedidata (United States)JGJoshua J. GagneJohnson & Johnson (United States)NCNiteesh K. ChoudhryPreventive Cardiology

Discussion

Member takes

Implication

Informs shared decision-making on anticoagulants but should not change practice; hypothesis-generating for preference-based trials.

Structured PICO

How do patients with cardiovascular disease weigh the relative benefits and risks of anticoagulant therapy?

Population

341 US patients with cardiovascular disease from an online panel

Intervention

Discrete Choice Experiment scenarios describing hypothetical anticoagulant treatments (new drug, old drug, or no drug)

Outcome

Patient preferences for benefits and risks of anticoagulant therapy (nonfatal stroke, nonfatal myocardial infarction, cardiovascular death, minor bleeding, major bleeding, bleeding death, and need for monitoring)patient reported

Patients with cardiovascular disease weigh the risk of fatal bleeding more heavily than nonfatal ischemic events or cardiovascular death when considering anticoagulant therapy, with preferences influenced by prior clinical events.

Cite This Study

Najafzadeh et al. (2014) studied this question.

synapsesocial.com/papers/6a1d6a85266863fda62f3bdf https://doi.org/10.1161/circoutcomes.114.001013

Topics

Women and heart disease Anticoagulation in AF

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Patients’ Preferences in Anticoagulant Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Patients’ Preferences in Anticoagulant Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider