Key result
Ethanolic extract of Justicia gendarussa administered for 7 days attenuated doxorubicin-induced disturbance of oxido-reduction status and histopathology in mice heart tissue.
Why the study?
Justicia gendarussa has widely reported antioxidant and anti-inflammatory properties, but its potential cardioprotective effect against doxorubicin-induced toxicity had not been evaluated.
Does Justicia gendarussa extract prevent doxorubicin-induced cardiotoxicity in mice?
Does Justicia gendarussa extract prevent doxorubicin-induced cardiotoxicity in mice?
Justicia gendarussa extract shows potential cardioprotective effects against doxorubicin-induced toxicity in a mouse model by restoring oxido-reduction status.
Attenuates doxorubicin cardiotoxicity in mice; leaves open human translation and requires clinical trials.
Justicia gendarussa Burm.f, belonging to the family Acanthaceae, is widely used for various ailments traditionally. Antioxidant, anti-arthritic, anti-inflammatory, analgesic, anticancerous, properties of the plant have been widely reported. The present study analyzed the cardioprotective effect of J. gendarussa on doxorubicin (DOX) induced toxicity in mice. Ethanolic extract of J. gendarussa was administered orally for 7 consecutive days. The alterations in oxido-reduction status, biochemical and histopathological parameters were analyzed in heart tissue. DOX increased superoxide dismutase (SOD) and catalase activities to 3.4 ± 0.5 and 3.68 ± 1 from their normal values 2.43 ± 0.8 and 2.72 ± 0.88, respectively. The increased activities of both the enzymes were found reduced to 3.12 ± 0.24 and 3.41 ± 0.65 by the treatment of the extract. Similarly, DOX elevated glutathione peroxidase (GPx) activity to 44.6 ± 3.71 from the normal level 32.33 ± 3.41. DOX decreased the glutathione (GSH) level to 15.66 ± 2.51 from the normal values 31.66 ± 4.05. Upon treatment, GPx activity and GHS level found restored. The increased lipid peroxidation 2.53 ± 0.25 of DOX was also decreased to 2.0 ± 0.34 by the extract. Histopathology observations substantiate the protective effect of J. gendarussa extract. In conclusion, DOX-induced disturbance of oxido-reduction status and histopathology of heart attenuated closer to the normal indicating the protective effect of J. gendarussa against DOX-induced toxicity in cardiomyocytes.
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Sreepriya et al. (2022) studied Doxorubicin-induced cardiotoxicity. Ethanolic extract of Justicia gendarussa vs. Doxorubicin alone was evaluated on Oxido-reduction status, biochemical and histopathological parameters in heart tissue. Ethanolic extract of Justicia gendarussa administered for 7 days attenuated doxorubicin-induced disturbance of oxido-reduction status and histopathology in mice heart tissue.
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