What does this research mean for the field?

Skeletal muscle sarcolemmal lactate transport capacity is significantly higher in red muscle fibers compared to white muscle fibers and decreases substantially with age. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1991Acta Physiologica Scandinavica

Muscle lactate transport studied in sarcolemmal giant vesicles: dependence on fibre type and age

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Population

Sarcolemmal giant vesicles from rat or rabbit skeletal muscle, and single mouse muscle fibers.

Comparison

Equilibrium exchange experiments with 10, 30… vs White muscle vesicles and 2-month-old animals.

Design

Preclinical

Authors

CJCarsten JuelUniversity of Copenhagen AHA. HönigNorfolk State University HPHenriette PilegaardUniversity of Copenhagen

Discussion

Member takes

Implication

Rodent vesicle data on lactate transport should not guide practice; leaves open human relevance and need for translational studies.

Structured PICO

Population

Sarcolemmal giant vesicles from rat or rabbit skeletal muscle, and single mouse muscle fibers (comparing red vs. white muscle, and 2-month-old vs. 18- or 22-month-old animals).

Intervention

Equilibrium exchange experiments with 10, 30, and 60 mM lactate.

Comparator

White muscle vesicles (vs red) and 2-month-old animals (vs 22-month-old or 18-month-old).

Outcome

Lactate transport capacity and initial exchange flux.surrogate

Lactate transport capacity in skeletal muscle is fiber-type dependent (higher in red muscle) and decreases with age.

Cite This Study

Juel et al. (1991) studied this question.

synapsesocial.com/papers/6a1d6d201c2cbcb15c5e49d0 https://doi.org/10.1111/j.1748-1716.1991.tb09246.x

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December 1, 1991Acta Physiologica Scandinavica

Muscle lactate transport studied in sarcolemmal giant vesicles: dependence on fibre type and age

View Full Paper

Ask AI

Bookmark

Population

Sarcolemmal giant vesicles from rat or rabbit skeletal muscle, and single mouse muscle fibers.

Comparison

Equilibrium exchange experiments with 10, 30… vs White muscle vesicles and 2-month-old animals.

Design

Preclinical

Authors

CJCarsten JuelUniversity of Copenhagen AHA. HönigNorfolk State University HPHenriette PilegaardUniversity of Copenhagen

Discussion

Member takes

Implication

Rodent vesicle data on lactate transport should not guide practice; leaves open human relevance and need for translational studies.

Structured PICO

Population

Sarcolemmal giant vesicles from rat or rabbit skeletal muscle, and single mouse muscle fibers (comparing red vs. white muscle, and 2-month-old vs. 18- or 22-month-old animals).

Intervention

Equilibrium exchange experiments with 10, 30, and 60 mM lactate.

Comparator

White muscle vesicles (vs red) and 2-month-old animals (vs 22-month-old or 18-month-old).

Outcome

Lactate transport capacity and initial exchange flux.surrogate

Lactate transport capacity in skeletal muscle is fiber-type dependent (higher in red muscle) and decreases with age.

Cite This Study

Juel et al. (1991) studied this question.

synapsesocial.com/papers/6a1d6d201c2cbcb15c5e49d0 https://doi.org/10.1111/j.1748-1716.1991.tb09246.x

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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