Key result
Synaptic dysfunction and oscillatory abnormalities in thalamocortical circuits, as modeled by 22q11.2 deletion syndrome, may underlie the diverse symptoms of schizophrenia.
Why the study?
Understanding of the neural circuits underlying schizophrenia symptoms remains in early stages, contributing to stagnant therapeutic development and poor prognosis.
Design
Review
Authors
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Thalamocortical model in 22q11.2 schizophrenia remains hypothesis-generating; leaves open clinical translation pending validation.
This review proposes a model where the thalamus acts as a central vulnerable hub, and its dysfunction can explain the diverse positive, negative, and cognitive symptoms of schizophrenia.
Jiang et al. (2021) conducted a review in Schizophrenia. Synaptic dysfunction and oscillatory abnormalities in thalamocortical circuits, as modeled by 22q11.2 deletion syndrome, may underlie the diverse symptoms of schizophrenia.
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