Why the study?
Does cardiopulmonary bypass accelerate progression to AIDS in HIV-positive intravenous drug addicts undergoing cardiac surgery?
Does cardiopulmonary bypass accelerate progression to AIDS in HIV-positive intravenous drug addicts undergoing cardiac surgery?
In a small case series, cardiopulmonary bypass during cardiac surgery for infective endocarditis did not appear to accelerate progression to AIDS in HIV-positive patients.
Case series suggests no CPB-AIDS link; hypothesis-generating and should not yet change practice in HIV patients.
In the last years the number of HIV-positive patients needing cardiac surgery has greatly increased. Cardiopulmonary bypass is suspected to have a role in the progression of HIV-infection to acquired immunodeficiency syndrome (AIDS). From October 1988 to December 1990, 6 intravenous drug addicts underwent cardiac surgery for infective endocarditis at our Department. Preoperative and postoperative absolute lymphocyte T-helper (CD4) and T-suppressor (CD8) counts did not show a close association between the temporary lymphopenia induced by cardiopulmonary bypass and progression to AIDS.
No takes yet. Share an insight, caveat, or question.
Lemma et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: