What does this research mean for the field?

A low-protein diet in dogs causes a progressive decline in serum albumin and total protein, while nitrogen is primarily lost from tissues, demonstrating that tissue proteins can be catabolized to maintain or regenerate plasma protein levels. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1935The Journal of Experimental MedicineOpen Access

Nutritional Edema in the Dog

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Population

Dogs

Design

Preclinical

Follow-up

up to 42 metabolism periods of approximately 7 days each

Authors

AWA. A. WeechJohns Hopkins University EGE. GoettschUniversity of Southern California EREdwina ReevesUniversity of Liberia

Discussion

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Implication

These canine findings should not inform human nutrition; they leave open tissue nitrogen dynamics in protein restriction for clinical investigation.

Structured PICO

Population

Dogs (n=38 for normal serum analysis, n=19 for normal plasma analysis, n=21 for low protein diet experiment, n=5 for nitrogen balance)

Intervention

Low protein diet

Outcome

Concentration of protein in serum and plasma (albumin, globulin, total protein)surrogate

A low protein diet in dogs leads to a progressive decline in serum proteins, primarily albumin, with nitrogen loss occurring mostly from tissues rather than circulating protein.

Cite This Study

Weech et al. (1935) studied this question.

synapsesocial.com/papers/6a1d6f0b73c56dd1bd2fac2b https://doi.org/10.1084/jem.61.3.299

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Implication

These canine findings should not inform human nutrition; they leave open tissue nitrogen dynamics in protein restriction for clinical investigation.

Nutritional Edema in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nutritional Edema in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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