Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B.
Population
Hep G2 cells
Comparison
Oleate addition (0.1 mM to 0.8 mM) vs Absence of oleate
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May affect hepatic lipoprotein production; leaves open relevance to human dyslipidemia.
Structured PICO
P
Population
Hep G2 cells
I
Intervention
Oleate addition (0.1 mM to 0.8 mM)
C
Comparator
Absence of oleate
O
Outcome
Secretion rate of apolipoprotein B (apoB)-containing lipoproteins and intracellular degradation of apoBsurrogate
Oleate stimulates the secretion of apolipoprotein B from Hep G2 cells by protecting nascent apoB from early intracellular degradation.
Cite This Study
Dixon et al. (1991) studied this question.