What question did this study set out to answer?

Determine absolute optical pathlengths and differential pathlength factors (DPF) across adult and newborn tissues to characterize statistical and anatomical variation using phase-resolved near-infrared spectroscopy.

February 1, 1995Physics in Medicine and Biology

Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy

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Determine absolute optical pathlengths and differential pathlength factors (DPF) across adult and newborn tissues to characterize statistical and anatomical variation using phase-resolved near-infrared spectroscopy.
Measured optical pathlengths across 100 adults (head, calf, forearm) and 35 newborn infants (head) using a portable intensity-modulated optical spectrometer.
Conducted 5-second measurements at a modulation frequency of 200 MHz using source-detector spacings > 4 cm across four wavelengths (690 nm, 744 nm, 807 nm, and 832 nm).
Differential pathlength factors at 807 nm were 4.16 (±18.8%) for the adult forearm, 5.51 (±18%) for the adult calf, 6.26 (±14.1%) for the adult head, and 4.99 (±9%) for the newborn infant head.
DPF values demonstrated wavelength dependence across all measured anatomical sites, alongside sex-specific differences in the adult forearm and calf.

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Implication

Cross-sectional study reports tissue-specific differential pathlength factors across four wavelengths in adults and newborns, highlighting improved quantification of chromophore concentration changes.

Cite This Study

Duncan et al. (1995) studied this question.

synapsesocial.com/papers/6a1d706873c56dd1bd2fae5b https://doi.org/10.1088/0031-9155/40/2/007

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Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy

Key Points

Discussion

Implication

Cite This Study

Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy

Key Points

Discussion

Implication

Cite This Study

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