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Novel catalysts enhance enantioselectivity and reaction rates in quaternary center assembly, suggesting improved synthetic efficiency.
We report the discovery of novel N,N'-disubstituted cinchona alkaloids as efficient phase-transfer catalysts for the assembly of stereogenic quaternary centers. In comparison to traditional cinchona-alkaloid-based phase-transfer catalysts, these new catalysts afford substantial improvements in enantioselectivity and reaction rate for intramolecular spirocyclization reactions with catalyst loadings as low as 0.3 mol% under mild conditions.
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Xiang et al. (2014) studied this question.
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