What is the clinical evidence from this study?

Study design: Cohort. Population: Coronary heart disease (n=956). Intervention: Tricyclic antidepressants (TCA) vs. Antidepressant non-use. Primary outcome: Mortality (HR 1.74, 95% CI 1.12-2.69, p=0.01).

What does this research mean for the field?

Tricyclic antidepressant (TCA) use in patients with coronary heart disease is associated with increased mortality compared to non-use, an effect that is at least partially mediated by differences in autonomic function. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study investigates the impact of tricyclic antidepressants (TCA) and selective serotonin reuptake inhibitors (SSRI) on mortality among patients with coronary heart disease, focusing on autonomic function as a mediating factor.

March 25, 2014Psychological Medicine

Antidepressants, autonomic function and mortality in patients with coronary heart disease: data from the Heart and Soul Study

View Full Paper

Ask AI

Bookmark

Key result

Tricyclic antidepressant use in patients with coronary heart disease was associated with increased mortality compared with non-use (HR 1.74; 95% CI 1.12-2.69; p=0.01).

Authors

FZFrank Zimmermann‐ViehoffUniversity of Potsdam LKLinn K. KuehlMSB Medical School Berlin HDHeidi Danker‐HopfeHumboldt-Universität zu Berlin

Discussion

Member takes

Implication

TCA use in CHD warrants caution; observational link leaves open autonomic mediation and needs prospective confirmation.

Key Points

This study investigates the impact of tricyclic antidepressants (TCA) and selective serotonin reuptake inhibitors (SSRI) on mortality among patients with coronary heart disease, focusing on autonomic function as a mediating factor.
Followed 956 patients with coronary heart disease for a mean duration of 7.2 years
Assessed autonomic function via heart rate variability and norepinephrine levels
Compared mortality rates among TCA users, SSRI users, and non-users of antidepressants.
52.3% of TCA users died by the end of follow-up (HR 1.74, 95% CI 1.12-2.69, p=0.01)
38.2% of SSRI users died (HR 1.15, 95% CI 0.81-1.64, p=0.44)
Adjusting for autonomic function reduced the TCA mortality association (HR 1.27, 95% CI 0.67-2.43, p=0.47).

Study Design

Type

Cohort (n=956)

PICO

Population

Coronary heart disease (n=956)

Intervention / Comparator

Tricyclic antidepressants (TCA) vs Antidepressant non-use

Primary Outcome

Mortality — HR 1.74 (1.12-2.69), p=0.01

Main Result

Effect estimate: HR 1.74 (95% CI 1.12-2.69)

Absolute Event Rate: 52.3% vs 37.3%

p-value: p=0.01

Cite This Study

Zimmermann‐Viehoff et al. (2014) conducted a cohort in Coronary heart disease (n=956). Tricyclic antidepressants (TCA) vs. Antidepressant non-use was evaluated on Mortality (HR 1.74, 95% CI 1.12-2.69, p=0.01). Tricyclic antidepressant use in patients with coronary heart disease was associated with increased mortality compared with non-use (HR 1.74; 95% CI 1.12-2.69; p=0.01).

synapsesocial.com/papers/6a1d70b633e2df9c962f8536 https://doi.org/10.1017/s003329171400066x

View Full Paper

Ask AI

Bookmark

Antidepressants, autonomic function and mortality in patients with coronary heart disease: data from the Heart and Soul Study

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Antidepressants, autonomic function and mortality in patients with coronary heart disease: data from the Heart and Soul Study

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Cite This Study

Also Consider

Also Consider