Maintaining ≥7% weight loss at 1 year following intensive lifestyle intervention in patients with diabetes was associated with superior sustained weight loss (-11.0% vs -4.0%, p<0.001) at 15 years.
Cohort
Does maintaining ≥ 7% weight loss at 1 year following intensive lifestyle intervention improve long-term cardiometabolic outcomes in patients with diabetes and obesity?
Achieving and maintaining ≥ 7% weight loss at 1 year through intensive lifestyle intervention in patients with diabetes and obesity is associated with sustained improvements in weight and glycemic control at 15 years.
Absolute Event Rate: -11% vs -4%
p-value: p=<0.001
INTRODUCTION: We previously demonstrated that achieving and maintaining ≥ 7% weight loss at 1 year in patients with diabetes (DM), through multidisciplinary intensive lifestyle intervention (ILI) in real-world clinical practice, predicts improvement in cardiometabolic outcomes at 5 and 10 years. In this prospective follow-up, we report 15-year results. METHODS: ) who completed a 12-week ILI program. The cohort achieved an average weight loss of 10.7 ± 4.6 kg (-9.6%, p < 0.001) at 12 weeks and was divided into two groups at 1 year: group A, who maintained < 7% weight loss (47.5%) and group B, who maintained ≥ 7% weight loss (52.5%). RESULTS: At 15 years, the cohort maintained an average weight loss of 8.6 ± 11.9 kg (-7.6%, p < 0.001). Group B demonstrated superior sustained weight loss (12.9 ± 12.0 kg, -11.0%) compared to group A (3.8 ± 10.0 kg, -4.0%) with p < 0.001 between groups. A1C in group B improved from 7.3% ± 1.1% to 6.3% ± 0.8% at 12 weeks and remained at 7.3% ± 1.5% at 15 years, while group A's A1C increased from 6.7% ± 0.9% to 7.9% ± 1.8% (p = 0.04 between groups). Both groups maintained LDL- and HDL-cholesterol improvements, but group A experienced significant worsening of serum triglycerides. CONCLUSIONS: ILI in real-world clinical practice that results in ≥ 7% weight loss at 1 year in patients with DM and obesity is associated with continued improvement in cardiometabolic outcomes at 15 years.
Khater et al. (Sat,) conducted a cohort in Diabetes and obesity. Intensive lifestyle intervention maintaining ≥ 7% weight loss at 1 year vs. Maintaining < 7% weight loss at 1 year was evaluated on Sustained weight loss at 15 years (p=<0.001). Maintaining ≥7% weight loss at 1 year following intensive lifestyle intervention in patients with diabetes was associated with superior sustained weight loss (-11.0% vs -4.0%, p<0.001) at 15 years.