Key result
Intensive lifestyle intervention reduces mild or greater depression symptoms ~15% vs. diabetes support and education.
Why the study?
Does an intensive lifestyle intervention reduce depression symptoms and improve health-related quality of life in overweight/obese individuals with type 2 diabetes?
Population
5,145 overweight/obese individuals with type 2 diabetes
Comparison
Intensive lifestyle intervention designed to… vs Diabetes support and education control…
Design
RCT, randomized
Follow-up
median of 9.6 years
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Supports intensive lifestyle intervention for depression prevention in type 2 diabetes; extends prior evidence to mental health outcomes.
RCT (n=5,145)
Yes
Does an intensive lifestyle intervention reduce depression symptoms and improve health-related quality of life in overweight/obese individuals with type 2 diabetes?
Hazard Ratio: 0.85 (95% CI 0.75–0.97)
p-value: p=0.0145
An intensive lifestyle intervention in overweight or obese patients with type 2 diabetes reduces the risk of developing clinically significant depression symptoms and preserves physical health-related quality of life over nearly a decade.
A 2014 study conducted an RCT in Type 2 diabetes (n=5,145). Intensive lifestyle intervention (ILI) vs. Diabetes support and education (DSE) was evaluated on Incidence of mild or greater depression symptoms (BDI scores ≥10) (HR 0.85, 95% CI 0.75-0.97, p=0.0145). Intensive lifestyle intervention significantly reduced the incidence of mild or greater depression symptoms compared with diabetes support and education (HR 0.85; 95% CI 0.75-0.97; P=0.0145).
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