Why the study?
Does the LDL receptor mediate cell entry of Flaviviridae viruses in cultured cells?
Population
Cultured cells (including LDL receptor-deficient cells and cells resistant to BVDV infection)
Comparison
Inhibition of LDL receptor activity vs Control/uninhibited state
Design
Preclinical
Authors
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LDL receptor blockade may inhibit Flaviviridae entry in vitro; leaves open translation to animal models or human therapy.
Does the LDL receptor mediate cell entry of Flaviviridae viruses in cultured cells?
Demonstrates that Flaviviridae viruses utilize the LDL receptor for cell entry by complexing with VLDL or LDL.
Agnello et al. (1999) studied this question.
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