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March 1, 1994Proceedings of the National Academy of SciencesOpen Access

RGD sequence of foot-and-mouth disease virus isessential for infecting cells via the natural receptor but can be bypassed by anantibody-dependent enhancement pathway.

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Population

Baby hamster kidney (BHK) cells and Chinese hamster ovary cells expressing an immunoglobulin Fc receptor

Comparison

Synthetic full-length viral RNAs mutated within… vs Wild-type viral RNAs

Design

Preclinical

Authors

PMPeter W. MasonNovartis (United States)ERElizabeth RiederNational Agricultural Statistics ServiceBBBarry BaxtAgricultural Research Service

Discussion

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Implication

Confirms RGD essentiality for FMDV entry; leaves open antibody-dependent enhancement as alternative pathway, hypothesis-generating only.

Structured PICO

P
Population
Baby hamster kidney (BHK) cells and Chinese hamster ovary cells expressing an immunoglobulin Fc receptor
I
Intervention
Synthetic full-length viral RNAs mutated within or near the RGD sequence of the viral capsid protein VP1
C
Comparator
Wild-type viral RNAs
O
Outcome
Viral infectivity and cell bindingsurrogate

The RGD sequence is essential for foot-and-mouth disease virus binding to susceptible cells, but this natural receptor pathway can be bypassed via antibody-dependent enhancement.

Cite This Study

Mason et al. (1994) studied this question.

synapsesocial.com/papers/6a1d75331c2cbcb15c5e57e2https://doi.org/10.1073/pnas.91.5.1932
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  3. 3Synthesis of infectious poliovirus RNA by purified T7 RNA polymerase.1986 · 343 citations
  4. 4Analysis of neutralizing epitopes on foot-and-mouth disease virus1988 · 101 citations
  5. 5Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice1993 · 180 citations